The purpose of our study was to determine the ability of h1 mr spectroscopy mrs to lateralize the lesion in patients with hippocampal sclerosis. Single voxel proton mr spectroscopy in toluene abuse. We expect that the accurate detection of lactate and lipids will have high diagnostic value in the diagnosis of brain tumors. Conventional magnetic resonance imaging mri is essential for the management of childhood brain tumours. Proton spectroscopy is easy to perform at clinically used whole body mr scanners, since the necessary. Methods 21 patients with juvenile or adult mld 12 hcttreated were compared with 16 controls in the. Recently, singlevoxel proton mr spectroscopy, performed at 0. Detection and differentiation of lactate and lipids by.
As a standard of reference, a pointresolved spectroscopy press sequence was acquired. The purpose of this study was to investigate the use of. We studied 12 healthy volunteers and 21 patients with temporal lobe epilepsy refractory to medical treatment, which was clearly. Proton magnetic resonance spectroscopy in children with temporal lobe epilepsy.
In vivo detectability of a signal tcho from choline containing molecules at 3. The raw fid signal measured in the time domain underwent the following processing steps in order to extract the control signal. Singlevoxel proton mr spectroscopy of the basal ganglia in. Our aim in this study was to identify lactate and lipids by varying the echo time te. Singlevoxel spectroscopy svs techniques are the simplest to acquire and interpret, and hence are the most widely used. An in vivo threedimensional singlevoxel proton mrs brain examination. Wild and ian marshall department of medical physics, university of edinburgh, western general hospital, eh42xu, scotland introduction in previous studies 1, press localised csi images of stroke patients. Value of singlevoxel proton mr spectroscopy in temporal. To evaluate single voxel proton magnetic resonance mr spectroscopy in detection of abnormality of the upper motor neuron in patients with motor neuron diseases. Single voxel proton mr spectroscopy of nonneoplastic brain lesions suggestive of a neoplasm.
Comparison of singleshot localization methods steam and press for in vivo proton nmr spectroscopy. We examined 23 children with primary intracranial tumors detected by mri, and 32 controls with similar ages, using mrs on a 1. The response is mediated by relative changes in t2 which appear as changes in the image pixel intensities. Single voxel proton magnetic resonance spectroscopy of breast. We have proposed an application of functional singlevoxel proton spectroscopy fsvps for realtime studies at ultrahigh mr field which can be comparable to the epi bold fmri technique.
Elliott 4 and klaus mathiak 1,2,3 1 department of psychiatry, psychotherapy and psychosomatics, rwth aachen university, pauwelsstrasse 30, 52074 aachen, germany. T1weighted spin echo highresolution images showing the locations of three voxels in the left hemisphere of a normal subject. Optimization of single voxel mr spectroscopy sequence. This thesis investigates how pretreatment single voxel mrs can aid in diagnosis and surveillance of paediatric brain tumours and identify prognostic biomarkers.
Single voxel proton magnetic resonance spectroscopy of breast cancer at 3t. Pdf singlevoxel proton brain spectroscopy exam probesv. They were developed in the 1980s for the selection of magnetic resonance spectroscopy signals from a single voxel. The choice of singlevoxel mrs instead of chemicalshift imaging csi was made for two reasons. We examined 23 children with primary intracranial tumors detected by mri, and 32 controls with similar ages, using mrs on a. Mr spectroscopy could differentiate benign from malignant tumors but was not useful in grading malignant tumors. We studied 12 healthy volunteers and 21 patients with temporal lobe epilepsy refractory to medical treatment, which was clearly lateralized with electroencephalography. Evaluation of intracranial neoplasia and noninfectious. Comparison of multivendor singlevoxel mr spectroscopy data. Reproducibility of hippocampal singlevoxel proton mr spectroscopy and chemical shift imaging objective. In modern single voxel proton spectroscopy, the spatial selec. Singlevoxel proton mr spectroscopy of nonneoplastic brain lesions suggestive of a neoplasm. A case history is presented in which a b cell lymphoma with antecedent demyelinating lesions of the cns was suspected by mrs and confirmed by neuropathological examination and immunoglobulin gene rearrangement. Single voxel proton magnetic resonance spectroscopy mrs provides a rapid noninvasive fingerprint of tissue chemistry.
The single voxel proton brain exam probesv is an automated mr spectroscopic technique. Singlevoxel proton mr spectroscopy of nonneoplastic brain. Combination of singlevoxel proton mr spectroscopy and. This acquisition is fairly fast 1 to 3 minutes and a spectrum is easily obtained. Three mr spectra were obtained from the voxels of interest voi placed in the posterior centrum semiovale, thalamus and cerebellar white matter fig. A spinecho svps protocol without water suppression was acquired with 310 repetitions on a 7t siemens mr scanner tetr 20 ms, flip angle. They provide high signaltonoise in a relatively short scan time.
Usefulness of single voxel proton mr spectroscopy in the evaluation of hippocampal sclerosis keehyun chang, md, 1, 2, 3 hong dae kim, md, 1 sunwon park, md, 1 in chan song, phd, 2 in kyu yu, md, 1 moon hee han, md, 1, 2, 3 sang kun lee, md, 3, 4 chunkee chung, md, 3, 5 and yang hee park, md 6. Section of experimental mr of the cns, department of neuroradiology, hoppeseylerstr. Aug 18, 2005 the signals of lactate and lipids partially overlap in single voxel proton mr spectroscopy 1hmrs, sometimes making them difficult to differentiate in clinical settings. Objective to investigate regional differences of relative metabolite concentrations in the brain of healthy dogs with short echo time, single voxel proton magnetic resonance spectroscopy 1 h mrs at 3. Yet, standard localization methods do not guarantee.
Clinical proton mr spectroscopy in central nervous system disorders. Singlevoxel proton mr spectroscopy in toluene abuse. Single voxel proton spectroscopy for neurofeedback at 7. Reproducibility of hippocampal single voxel proton mr spectroscopy and chemical shift imaging objective. Volumeselective lactate editing has been performed successfully in vitro and in vivo in the brain on a clinical scanner using a pressbased single voxel 1 h spectroscopy and a 1 h spectroscopic imaging sequence. In vivo lactate editing in single voxel proton spectroscopy. Svs was acquired using a pointresolved spinecho sequence probep, ge medical systems.
Single voxel spectra are less susceptible to the effects of large. Value of singlevoxel proton mr spectroscopy in temporal lobe. Baseline correction in mr proton spectroscopy using bi. Regional metabolite concentrations in the brain of healthy. Nov 01, 2012 single voxel spectroscopy svs and multislice mrsi data were obtained during the same imaging session prior to contrast administration. Singlevoxel proton mr spectroscopy of the basal ganglia in patients with neurofibromatosis type 1 internal capsule, cerebellar white matter, dentate nu cleus, and cerebral white matter2 5. Detection and differentiation of lactate and lipids by single. Frontal brain lobe impairment in obstructive sleep apnoea.
We have proposed an application of functional singlevoxel proton spectroscopy fsvps for realtime studies at ultrahigh mr field which can be. Reproducibility of hippocampal singlevoxel proton mr. We expect that the accurate detection of lactate and lipids will have high diagnostic value in the diagnosis of. Singlevoxel spectroscopy versus chemicalshift imaging citeseerx. Request pdf singlevoxel proton mr spectroscopy in toluene abuse inhalation of toluene, which is an organic solvent, causes toxic encephalopathy characterized by cognitive impairment. However, it is increasingly being supplemented with functional techniques such as magnetic resonance spectroscopy mrs. Data from multiple centres, scanners from three leading manufacturers and field strengths of 1. Usefulness of single voxel proton mr spectroscopy in the evaluation of hippocampal sclerosis objective. Combination of singlevoxel proton mr spectroscopy and apparent. We investigated between and withinacquisition reproducibility of hippocampal metabolite ratios obtained using automated proton mr spectroscopy. Comparison of multivendor singlevoxel mr spectroscopy. The signals of lactate and lipids partially overlap in singlevoxel proton mr spectroscopy 1hmrs, sometimes making them difficult to differentiate in clinical settings.
Pdf singlevoxel proton mr spectroscopy in toluene abuse. Objective to determine whether proton magnetic resonance spectroscopic imaging is useful in predicting clinical course of patients with metachromatic leukodystrophy mld, an inherited white matter disorder treatable with haematopoietic cell transplantation hct. Mr research center, division of radiology, the cleveland clinic foundation, 9500 euclid avenue, cleveland, oh 44195 usa short echo time, single voxel localized proton spectroscopy was accomplished using a stimulated echo steam sequence running on a siemens 1. Spectroscopic signal quality was improved by manual calibration of the. A singlevoxel spectroscopy study of hippocampal metabolic. Because the imaged region is compact, excellent shimming can be obtained with resultant highquality spectra suitable for quantitative analysis. Multisite multivendor singlevoxel mr spectroscopy studies performed at 3. Comparison of single voxel and multivoxel proton mr spectroscopy in predicting 3 and 6 month neurologic outcome after adult traumatic brain injury. We evaluated whether the combination of these two techniques can. In vivo lactate editing in single voxel proton spectroscopy and proton spectroscopic imaging by homonuclear polarisation transfer. The voxel was selected at the motor cortex that was localized using a footstimulating task fmri. Single voxel proton magnetic resonance spectroscopy of. Localized singlevoxel spinecho proton mr spectroscopy. In svs, the signal is received of a volume limited to a single voxel.
Pdf combination of singlevoxel proton mr spectroscopy and. Usefulness of single voxel proton mr spectroscopy in the. The press sequence was made sensitive to homonuclear polarisation by replacing the standard 180 refocusing pulses with 90 pulses. Using 3plane standard clinical sequences, a radiologist with 7 years of experience in spinal mri positioned a single spectroscopy voxel in the center of the target vertebral body, which was devoid of any detectable focal lesion fig. Pdf singlevoxel proton mrs can be obtained with inversionbased, echo based, and hybrid methods. Review measurement sequences for single voxel proton mr. An automated shimming was used for more reliable reproducibility. Short echo time proton spectroscopy of human brain using a. Pdf the singlevoxel proton brain exam probesv is an automated mr spectroscopic technique.
Single voxel proton mr spectroscopy was carried out in all patients and in the age, sex and regionmatched 22 healthy control subjects on the same day with cranial mr imaging. Single voxel proton mr spectroscopy findings of typical. The singlevoxel proton brain exam probesv is an automated mr spectroscopic technique. Preoperative proton mr spectroscopic imaging of brain tumors. We report preliminary experience using singlevoxel, proton mr spectroscopy mrs employing small voxels of interest, in combination with short and long echotime protocols, for the assessment of primary intracranial tumors in children. Localized singlevoxel proton mr spectroscopy was ap plied to the right hippocampal area offive healthy volunteers at 1. Single and multivoxel proton spectroscopy in pediatric. Research papers abnormal brain chemistry in chronic back. Multisite multivendor single voxel mr spectroscopy studies performed at 3. Prost and victor haughton and kevin c y ho and safwan s.
The application of magnetic resonance fingerprinting to. Pdf localized singlevoxel magnetic resonance spectroscopy. Single voxel spectroscopy svs and multislice mrsi data were obtained during the same imaging session prior to contrast administration. Proton magnetic resonance spectroscopy of human cervical. Scientists and clinicians have contributed state of the art chapters on their respective areas of. Evaluation of intracranial neoplasia and noninfectious meningoencephalitis in dogs by use of short echo time, single voxel proton magnetic resonance spectroscopy at 3. We demonstrate the utility of such a magnetic resonance spectroscopic fingerprinting mrsf framework for simultaneously quantifying metabolite concentrations, t 1 and t 2 relaxation times and transmit inhomogeneity for major.
Quantitation of proton nmr spectra of the human brain using tissue water as an internal concentration reference. Quantitative mr spectroscopic imaging in metachromatic. Trte 1500 ms144 ms or 270 ms, averages 128, fov 22. Mr spectroscopy and apparent diffusion coefficient adc calculation have been used frequently for tumor grading and differentiation during the last decade. Four nonblinded readers ie, provided with clinical information and previous imaging studies were able to distinguish neoplastic from nonneoplastic. Single voxel spectroscopy svs techniques are the simplest to acquire and interpret, and hence are the most widely used.
Singlevoxel proton mr spectroscopy was carried out in all patients and in the age, sex and regionmatched 22 healthy control subjects on the same day with cranial mr imaging. Single voxel mr spectroscopic data were obtained by using a doublese pointresolved spectroscopy press sequence with onepulse water signal suppression mainly from metabolically active fleshy parts contrastenhanced areas of the lesions, while avoiding contamination from scalp fat. Measurement sequences for single voxel proton mr spectroscopy. Voxel volume was changed from 1 ml to 5 ml but other operatorde. In most cases, these processes were automatic, but, where spectra appeared distorted, manual processing was used, particularly for phase and baseline.
To study the value of different parameters derived from single voxel proton mr spectroscopy of the mesial temporal lobes in the lateralization of the epileptogenic zone in patients with temporal lobe epilepsy, methods. The aim is to assess whether tcho detectability can differentiate between benign and malignant breast. This thesis investigates how pretreatment single voxel mrs can aid in diagnosis and surveillance of paediatric brain tumours and identify prognostic. The most widely used single voxel spectroscopy methods are called press pointresolved spectroscopy, isis imageselected in vivo spectroscopy, and steam stimulated echo acquisition mode. We evaluated whether the combination of these two techniques can improve the diagnostic effectiveness of mr imaging in patients with brain tumors. Methods of cancer diagnosis, therapy, and prognosis. Single vs multivoxel magnetism questions and answers in mri. Objective to investigate metabolite concentrations of the brains of dogs with intracranial neoplasia or noninfectious meningoencephalitis by use of short echo time, single voxel proton magnetic resonance spectroscopy 1 h mrs at 3. Functional single voxel proton spectroscopy fsvps estimates the functional changes in t 2 from the unsuppressed water spectrum. Singlevoxel proton mr spectroscopy of the basal ganglia.
To study the value of different parameters derived from singlevoxel proton mr spectroscopy of the mesial temporal lobes in the lateralization of the epileptogenic zone in patients with temporal lobe epilepsy, methods. Proton magnetic resonance spectroscopy mrs appeals to many clinicians and. Comparison of single voxel and multi voxel magnetic. Echoplanar imaging epi in fmri is regularly used to reveal bold activation in presubscribed regions of interest roi. Single voxel proton spectroscopy for neurofeedback at 7 tesla. A single voxel spinecho press pointresolved spectroscopy sequence was used with echo time te 35 ms, repetition time tr 1,500 ms and 96 signal acquisitions, resulting in an acquisition time of 3 min per pixel. Singlevoxel mrs was obtained with point resolved spectroscopy sequence with water suppression. Singlevoxel proton mr spectroscopy and positron emission tomography for lateralization of refractory temporal lobe epilepsy.
Recently, single voxel proton mr spectroscopy, performed at 0. In the context of single voxel spectroscopy, fingerprinting can provide a unified framework for parameter estimation. Comparison of single voxel and multivoxel proton mr. The purpose of this study was to investigate the use of probesv as a diagnostic tool in patients with primary brain tumors and to compare our findings with the known information obtained from conventional nonautomated mr spectroscopic techniques. To evaluate singlevoxel proton magnetic resonance mr spectroscopy in detection of abnormality of the upper motor neuron in patients with motor neuron diseases. Pdf combination of singlevoxel proton mr spectroscopy. Singlevoxel proton brain spectroscopy exam probesv in. Single voxel proton spectroscopy for neurofeedback at 7 tesla yury koush 1,2,4, mark a. In 43 of 50 patients with motor neuron disease and 14 of 14 control subjects, matching sets of mr spectra were obtained in the left and right motor cortex.
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